Leptospirosis is a common infection in dairy and beef herds.

Economic losses result from

  • Infertility
  • Abortion
  • Poor milk yield

Leptospirosis is a common cause of abortion in dairy and beef herds

Leptospirosis can cause milk drop affecting a large proportion of the herd.

Leptospirosis affects humans causing influenza-like symptoms with severe headaches but can be treated effectively. Dairy farmers are particularly at risk of infection from urine splashing onto the face whilst milking the cows. Pasteurisation destroys all leptospire organisms excreted in milk.


The two important types of Leptospira hardjo are Leptospira borgpetersenii serovar Hardjo and Leptospira interrogans serovar Hardjo. Infection arises from contact with infected urine or the products of abortion. Disease is spread most often during the spring and summer months while cattle are at pasture. Leptospires are susceptible to drying, exposure to sunlight, pH<5.8 or extremes of temperature. Leptospira Hardjo is not carried by vermin or wildlife but sheep can carry and excrete Leptospira Hardjo therefore mixed grazing is a risk factor.

Disease is spread most often during the spring and summer months while cattle are at pasture.

The important risk factors for leptospirosis are:

  • Open herds
  • Using shared bulls
  • Mixed grazing with sheep
  • Shared grazing with common watercourses

Clinical presentation

A sudden drop in milk yield occurs two to seven days after infection of susceptible cows. The udder becomes soft and flabby with colostrum-like secretions or blood-tinged milk in all quarters. Signs may be mild and go undetected but some cows become lethargic and stiff with a fever and reduced appetite. Abortion may occur three to 12 weeks following infection with most abortions occurring during the last three months of pregnancy. Infection may also produce premature and weakly calves.

There is circumstantial evidence of infertility following isolation of Leptospira Hardjo from the reproductive tract of a high percentage of repeat breeder cows. Leptospira Hardjo may also cause embryonic death. Venereal transmission is possible but may not adversely affect the pregnancy rate because Leptospira Hardjo is killed by uterine defences during oestrus. Split-herd vaccination trials have shown improved fertility parameters in vaccinated cows in herds with endemic Leptospira Hardjo infection.

Differential diagnoses

There are numerous causes of a marked drop in the volume of milk recorded from the bulk tank which your veterinary practitioner will consider (large numbers of cows affected) including:

  • sudden changes in feeding regimen,
  • bovine virus diarrhoea infection (BVDV)
  • lungworm infestation,
  • infectious bovine rhinotracheitis (IBR),
  • bovine respiratory syncytial virus (BRSV),
  • influenza A.
  • Salmonellosis

The common causes of abortion include

  • Neospora caninum
  • BVDV infection
  • Salmonella spp.
  • Bacillus licheniformis
  • Campylobacter


Various tests detect antibodies to Leptospira Hardjo in blood samples with serum MAT titres of >1/100 considered to be significant.

Abortion Diagnosis:

Dam Serology

Dam serology is of limited use because the MAT titre may fall rapidly after acute infection and be negative at the time of abortion; a positive result may only reflect previous exposure. During an abortion outbreak MAT titres >1/400 in some aborted cows are likely to be meaningful. ELISA titres are reported to remain positive for much longer following infection so may simply indicate previous exposure.

Aborted Foetus

Antibodies in foetal fluids may indicate exposure to Leptospira Hardjo in utero after four months' gestation however the foetus may die before mounting an immune response.

Fluorescent antibody test (FAT) to detect Leptospira Hardjo antigen in foetal tissues, e.g. kidney and lung is the best available test to confirm a diagnosis of abortion but delays in sample submission lead to rapid sample autolysis adversely affecting the test.

Herd screening tests

A bulk milk ELISA test is available and can be monitored regularly as part of surveillance programme in a naïve herd. Pooling milk samples from first lactation heifers is a useful way of monitoring the infection status in a herd.

Control of Leptospira Hardjo in cattle herds relies upon a combination of management decisions to reduce risk of infection, strategic antibiotic treatment, and vaccination. The primary course of immunisation consists of two injections four weeks apart followed by annual boosting. Vaccination should prevent urine shedding following exposure and will protect against milk drop and abortion.